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Selective protein turnover is important for the survival of all organisms. Mycobacterium tuberculosis and related bacteria rely on processive protein degradation pathways in order to survive adverse conditions encountered in their environment or inside the infected host. We investigate large, compartmentalizing degradation complexes and their substrate recruitment mechanisms, including the mycobacterial proteasome and a ubiquitin-like, post-translational protein modification termed pupylation that recruits substrates for proteasomal degradation.



» Our paper on the structural basis of Pup translocation by Mpa is online, see external pagehere

» Our paper on a new mechanism of transcription activation in mycobacteria is online, see external pagehere

» Eilika is elected as one of the 64 new EMBO members. You can find the full press release external pagehere




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